Mast cell tumors are among the most common skin cancers in dogs, especially in breeds like Boxers, Bulldogs, and Labrador Retrievers. This comprehensive guide explains what mast cell tumors are, their causes, risk factors, symptoms, diagnosis, and treatment options. Learn how to recognize warning signs such as skin lumps, redness, ulcerated masses, and systemic symptoms that may indicate histamine release. Early detection is critical for improving outcomes, and proactive cancer screening can make a lifesaving difference. Discover how Oncotect, a non-invasive urine-based wellness screen for cancer, helps pet parents detect mast cell tumors and other cancers early — often before visible symptoms appear. With simple at-home urine collection, Oncotect provides peace of mind and enables timely veterinary care. Whether your dog is a senior or a high-risk breed, staying ahead with early screening ensures more options, better outcomes, and a higher quality of life.